科瑞娜·梅德博士.D.
- Associate Professor & 化学的椅子 , 化学
When I first learned about DNA, I was fascinated with the question of how a compound with such simplicity could give us all the diversity we see in the world. It was with that question in mind that I chose to venture into biochemistry. After completing my undergraduate degree in 生物化学 here at 澳门金沙线上赌博官网, I went on to obtain a doctoral degree in 摩尔ecular Biophysics at the Johns Hopkins University with David E. 德雷伯. I then crossed the country to San Francisco for a postdoctoral fellowship at University of California, San Francisco with Christine Guthrie. Each experience brought me a new set of tools to approach my questions, which had only grown in complexity with the more I learned. 一路走来, I was also continually reminded how much I loved the interplay between teaching and research. Therefore, I sought out positions where teaching and research were partnered. This brought me back to Texas, and ultimately to 澳门金沙线上赌博官网.
研究 in the maed Lab centers on characterizing a key mechanism in gene expression, pre-messenger RNA 拼接. Splicing precisely removes non-protein coding sequences from RNA prior to translation into proteins. The mechanism involves large-scale rearrangements of protein-RNA complexes, which must be regulated to ensure both 拼接 timing and accuracy. Our current work focuses on identifying the mechanisms by which several essential 拼接 proteins regulate spliceosome assembly and activation. We use a variety of biochemical, molecular biological, and genetics techniques to dissect the importance of protein-nucleic acid and protein-protein interactions in the spliceosome.